Late 13th c. - first quarter of 14th c.: Anna Anachoutlou, the daughter of Alexios II Grand Komnenos (1297-1330), is born in Trebizond.

Before July 4, 1341: Anna becomes a nun in Jerusalem (Monastery of St. Euthymios). In 1340 she goes to the Pontos and mounts resistance against Eirene Palaiologina (1340‑1341) in Lazia.

Spring - summer 1341: The Türkmen of Amida attack Lazia.

July 4, 1341: The Türkmen of Amida attack, invade, plunder and burn Trebizond before they withdraw. Empress Eirene Palaiologina is forced to resign.

July 17, 1341: Anna Anachoutlou (Grand Komnene) is crowned empress, supported by the people of the provinces and the Amytzantarios family.

July 30, 1341: Michael Grand Komnenos arrives in Trebizond as usurper.

August 7, 1341: Michael Grand Komnenos is arrested by the Laz warriors of Anna Anachoutlou.

August 10, 1341: The exiled Eirene Palaiologina (1340‑1341) is compelled to travel to Constantinople.

After August 10, 1341: Aristocrats of Trebizond travel to Constantinople, where they join John Grand Komnenos against Anna Anachoutlou.

Summer 1342: John, subsequent John III Grand Komnenos (1342‑1344), sails from Constantinople to Trebizond as the usurper to the throne of Anna Anachoutlou.

August 1342: Anna Anachoutlou defeats the Türkmen of Amida in Lazia.

Late August - early September 1342: Anna Anachoutlou is deposed by the Scholarios family and their allies.

September 3, 1342: Anna Anachoutlou (Grand Komnene) is strangled.

September 4, 1342: John Grand Komnenos arrives in Trebizond and is crowned as John III (1342‑1344) in the church of Theotokos Chrysokephalos.

After September 4, 1342: Political ascent of the Scholarios family, persecutions against the Amytzantarios family, massacres of followers of Anna Anachoutlou.